Hydrochloric Acid → 1-Ethylpiperidine-2,4-dione

HRID 569989Notes

Reaction equation

HRID 569989 reaction equation
C([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][N:8]([CH2:13][CH3:14])[C:7]1=[O:15])(OCC)=O.Cl>>[CH2:13]([N:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH2:6][C:7]1=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13784118Ethyl 1-Ethyl-2,4-dioxopiperidine-3-carboxylate

Product 1

HCID 137841191-Ethylpiperidine-2,4-dioneYield 70%

Procedure

Added to 36.0 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione (Referential Example 35) was 300 ml of a 10% aqueous solution of hydrochloric acid. The resultant mixture was refluxed for 40 minutes. After allowing the reaction mixture to cool down, it was extracted with chloroform. The chloroform layer was washed with water, dried and then concentrated, thereby obtaining 16.6 g of 1-ethylpiperidine-2,4-dione as a light yellowish oily substance (yield: 70%).

Workup

  1. temperatureto cool down
  2. extractionit was extracted with chloroform
  3. washThe chloroform layer was washed with water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-03264042118a435a924dd981a1008270
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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