HCID 13784124, compound → HCID 13784125, compound

HRID 569994Notes

Reaction equation

HRID 569994 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:22](=[O:23])[NH:21][CH2:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CC(O)=O>[N:11]1([C:14]2[N:15]=[CH:16][C:17]3[C:22](=[O:23])[NH:21][CH2:20][C:18]=3[N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 13784124HCID 13784124, compound

Product 1

HCID 13784125HCID 13784125, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

While heating at 60° C. 1.6 g (5.18 mmol, Referential Example 42) of 2-(4-benzylpiperazino)-5-oxo-5,6-dihydro(7H)pyrrolo[3,4-d]pyrimidine, 0.16 g of 10% Pd-C and 30 ml of AcOH, H2 was bubbled. One hour later, Pd-C was filtered off and then the solvent was distilled off. The residue was suspended in a 10% aqueous NaHCO3 solution.

Workup

  1. filtrationOne hour later, Pd-C was filtered off
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-57770e55e1c34415ab250b86d61cf254
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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