Hydroxyamine hydrochloride → HCID 73187455, compound

HRID 569997Notes

Reaction equation

HRID 569997 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[CH:22][C:21]3[C:20](=O)[CH2:19][CH2:18][CH2:17][C:16]=3[N:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:26][OH:27]>CO>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[CH:22][C:21]3[C:20](=[N:26][OH:27])[CH2:19][CH2:18][CH2:17][C:16]=3[N:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 666551HCID 666551, compound

Product 1

HCID 73187455HCID 73187455, compoundYield 104.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Added to 30 ml of methanol were 2.6 g (8.07 mmol, Referential Example 48) of 2-(4-benzylpiperazino)-5-oxo-5,6,7,8-tetrahydroquinazoline and 0.67 g (9.64 mmol) of hydroxylamine hydrochloride. The resultant mixture was heated with stirring at 60° C. for 2 hours. The reaction mixture was cooled to 20° C. and the resultant precipitate was collected by filtration, thereby obtaining 2.85 g of white solid (yield: 95%).

Workup

  1. temperatureThe reaction mixture was cooled to 20° C.
  2. filtrationthe resultant precipitate was collected by filtration

Sources & evidence

ORD record
ord-8aa9ecf4d3df4871aae09debc868f5b7
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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