Acetic Acid → HCID 13784147, compound

HRID 570000Notes

Reaction equation

HRID 570000 reaction equation
C(O)(=O)C.[CH2:5]([N:7]1[C:13](=[O:14])[CH2:12][CH2:11][CH2:10][C:9]2[N:15]=[C:16]([N:19]3[CH2:24][CH2:23][N:22](CC4C=CC=CC=4)[CH2:21][CH2:20]3)[N:17]=[CH:18][C:8]1=2)[CH3:6].[H][H]>[Pd].C(O)C>[CH2:5]([N:7]1[C:13](=[O:14])[CH2:12][CH2:11][CH2:10][C:9]2[N:15]=[C:16]([N:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[N:17]=[CH:18][C:8]1=2)[CH3:6]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 13784146HCID 13784146, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13784147HCID 13784147, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixed solvent of 30 ml of acetic acid and 10 ml of ethanol, 0.6 g (2.18 mmol, Referential Example 52) of 5-ethyl-2-(4-benzylpiperazino)-6-oxo-6,7,8,9-tetrahydro(5H)pyrimido[5,4-b]azepine and 0.06 g of 10% Pd-C were added. While causing hydrogen gas to flow through the reaction mixture, the reaction was allowed to proceed at 100° C. for 4 hours. Thereafter, the Pd/C was filtered off and the filtrate was dried to obtain 0.5 g of a light yellowish oily substance (yield: about 100%).

Workup

  1. filtrationThereafter, the Pd/C was filtered off
  2. customthe filtrate was dried
  3. customto obtain 0.5 g of a light yellowish oily substance (yield: about 100%)

Sources & evidence

ORD record
ord-5437a0ef9812497db98b1e5265f69d9f
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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