HCID 13784145, compound → HCID 13784148, compound

HRID 570001Notes

Reaction equation

HRID 570001 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[NH:18][C:19](=[O:25])[CH2:20][CH2:21][CH2:22][C:23]=3[N:24]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[N:11]1([C:14]2[N:15]=[CH:16][C:17]3[NH:18][C:19](=[O:25])[CH2:20][CH2:21][CH2:22][C:23]=3[N:24]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 13784145HCID 13784145, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13784148HCID 13784148, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Added to 20 ml of ethanol were 0.1 g (0.3 mmol, Referential Example 51) of 2-(4-benzylpiperazino)-6-oxo-6,7,8,9-tetrahydro(5H)pyrimido[5,4-b]azepine and 0.01 g of 10% Pd-C. In a hydrogen atmosphere, they were reacted at 50° C. for 4 hours. After filtering off the Pd-C, the filtrate was dried to solid to obtain 0.074 g of colorless crystals in a quantitative yield.

Workup

  1. filtrationAfter filtering off the Pd-C
  2. customthe filtrate was dried to solid

Sources & evidence

ORD record
ord-2a475a732bf34714ad6ddc99372d86b4
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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