Acetic Anhydride → HCID 13784168, compound

HRID 570005Notes

Reaction equation

HRID 570005 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)[N:3]=1.[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[C:26]([NH:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:17][CH2:18]2)[N:3]=1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 13784166HCID 13784166, compound

Product 1

HCID 13784168HCID 13784168, compoundYield 61%

Procedure

In acetic anhydride, 1.00 g of ethyl 4-amino-2-(4-benzylpiperazino)pyrimidine-5-carboxylate (the compound synthesized in Referential Example 60) was refluxed for 1 hour. After allowing the reaction mixture to cool down, acetic anhydride was distilled off and the resulting viscous oil was purified by silica gel column chromatography to obtain 0.68 g of the above-identified compound (yield: 61%).

Workup

  1. temperaturewas refluxed for 1 hour
  2. temperatureto cool down
  3. distillationacetic anhydride was distilled off
  4. customthe resulting viscous oil was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-57c514ae91ed402c8a394622d36b6b3f
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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