反应详情

An ethanol solution of 25.2 g of sodium hydroxide was added with 160 g (0.60 mol) of 1-amidino-4-benzylpiperazine sulfate, followed by a dropwise addition of 129.4 g (0.60 mol) of diethyl ethoxymethylenemalonate over 20 minutes. After being refluxed for 5.5 hours, the reaction mixture was cooled and the precipitated crystals were collected by filtration. The thus-obtained crystals were washed with water and then dried, thereby obtaining 131.4 g of the above-identified compound (yield: 64%).

1. temperatureAfter being refluxed for 5.5 hours
2. temperaturethe reaction mixture was cooled
3. filtrationthe precipitated crystals were collected by filtration
4. washThe thus-obtained crystals were washed with water
5. customdried