反应详情

Refluxed for 2 hours in isoamyl alcohol (15 ml) were 0.63 g of 2-chloro-6,7-dimethoxyquinazoline (synthesized by the method described in Japanese Patent Laid-Open No. 36390/1972) and 0.72 g of anhydrous piperazine. Isoamyl alcohol was thereafter distilled off under reduced pressure, followed by extraction with 2N--NaOH and chloroform. The chloroform layer was washed with saturated saline and then dried with anhydrous magnesium sulfate. Chloroform was distilled off under reduced pressure to obtain 0.7 g of the intended product (yield: 91%).

1. customsynthesized by the method
2. distillationIsoamyl alcohol was thereafter distilled off under reduced pressure
3. extractionfollowed by extraction with 2N
4. washThe chloroform layer was washed with saturated saline
5. dry with materialdried with anhydrous magnesium sulfate
6. distillationChloroform was distilled off under reduced pressure