Pyrimidine → HCID 13769880, compound

HRID 570013Notes

Reaction equation

HRID 570013 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:22](=[O:23])[N:21]([CH:24]4[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)[CH2:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.N1C=CC=NC=1>C(O)C.[Pd]>[CH:24]1([N:21]2[C:22](=[O:23])[C:17]3[CH:16]=[N:15][C:14]([N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[N:19][C:18]=3[CH2:20]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

5

Reactant 2

HCID 9260PyrimidineHCID 13769879HCID 13769879, compound

Product 1

HCID 13769880HCID 13769880, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 702EthanolSolvent

Procedure

Dissolved in 30 ml of ethanol was 1.2 g (3.07 mmol, Referential Example 79) of 2-(4-benzylpiperazino)-6-cyclohexyl-5-oxo-5,6-dihydro(7H)pyrrolo-[3,4-d]pyrimidine, followed by an addition of 0.16 g of 10% Pd-C. The pyrimidine derivative was hydrogenated at 60° C. After completion of the reaction, Pd-C was filtered off and ethanol was distilled off to obtain 0.92 g of the above-identified compound as crystals (yield: about 100%).

Workup

  1. customwas hydrogenated at 60° C
  2. filtrationwas filtered off
  3. distillationethanol was distilled off

Sources & evidence

ORD record
ord-f2078e6c1239403b9c5d1d2b31b33e60
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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