Ethanol → HCID 13769894, compound

HRID 570014Notes

Reaction equation

HRID 570014 reaction equation
CCO.[CH3:4][NH:5][NH2:6].[CH2:7]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[N:25]=[C:24](Cl)[C:23]([C:27]([O:29]CC)=O)=[CH:22][N:21]=2)[CH2:16][CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(Cl)(Cl)Cl>[CH2:7]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[N:25]=[C:24]3[NH:6][N:5]([CH3:4])[C:27](=[O:29])[C:23]3=[CH:22][N:21]=2)[CH2:16][CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 6061MethylhydrazineHCID 13769893HCID 13769893, compound

Product 1

HCID 13769894HCID 13769894, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Added at room temperature (about 20° C.) to an EtOH solution (20 ml) of 2.0 g of 2-methylhydrazine was a chloroform solution (12 ml) of 5.3 g of the ethyl 2-(4-benzylpiperazino)-4-chloropyrimidine-5-carboxylate synthesized in Referential Example 63. The resultant mixture was stirred for 3 hours. The solvent was distilled off and ethyl acetate was added to the resultant solid. After thoroughly mixing the thus-obtained mixture, 3 g of crystals were collected by filtration (yield: 63%).

Workup

  1. customsynthesized in Referential Example 63
  2. distillationThe solvent was distilled off
  3. additionethyl acetate was added to the resultant solid
  4. additionAfter thoroughly mixing the thus-obtained mixture, 3 g of crystals
  5. filtrationwere collected by filtration (yield: 63%)

Sources & evidence

ORD record
ord-a3d811efa30e4f8fb165c70cf9b5120c
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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