Ethanol → HCID 13769894, compound

Participants

Reaction Steps

Added at room temperature (about 20° C.) to an EtOH solution (20 ml) of 2.0 g of 2-methylhydrazine was a chloroform solution (12 ml) of 5.3 g of the ethyl 2-(4-benzylpiperazino)-4-chloropyrimidine-5-carboxylate synthesized in Referential Example 63. The resultant mixture was stirred for 3 hours. The solvent was distilled off and ethyl acetate was added to the resultant solid. After thoroughly mixing the thus-obtained mixture, 3 g of crystals were collected by filtration (yield: 63%).

Provenance & Evidence