p-Toluenesulfonic acid → HCID 14097805, compound

HRID 570031Notes

Reaction equation

HRID 570031 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[C@H:12]1[NH:15][C:14](=[O:16])[C@H:13]1[NH:17]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(Cl)(Cl)Cl>[NH2:17][C@H:13]1[C@@H:12]([N:3]2[C:2](=[O:1])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4]2=[O:11])[NH:15][C:14]1=[O:16]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 14097802HCID 14097802, compound

Product 1

HCID 14097805HCID 14097805, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

(3S-cis)-4-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-[(triphenylmethyl)amino]-2-azetidinone(7 g) and 2.81 g of p-toluenesulfonic acid are stirred in 50 ml of chloroform for 1 hour at 0° C. and for 3 hours at room temperature. The title compound is collected.

Workup

  1. customThe title compound is collected

Sources & evidence

ORD record
ord-8810e9a751394992ba96cb74acb7dca0
Source dataset
uspto-grants-1988_03
Patent number
US04734496

Reaction notes

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