反应详情

A mixture of methyl 3-(4-fluorophenyl)-3-oxopropanoate (10.0 g, 0.051 mol) and hydrazine hydrate (1.1 eq, 2.8 g, 0.056 mol) in 20 mL glacial acetic acid is heated 3 h under reflux. The resulting suspension is cooled down and 10 mL diethyl ether is added. The precipitate is filtered off, dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol are obtained as white solid.

1. temperatureis heated 3 h
2. temperatureunder reflux
3. temperatureThe resulting suspension is cooled down
4. filtrationThe precipitate is filtered off
5. dry with materialdried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol
6. customare obtained as white solid