反应详情

温度

0 °C

688 mg (approx. 2.20 mmol, purity 92%) of 1-(2-fluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide were initially charged in 10 ml of ethanol and cooled to 0° C. 891 mg (8.80 mmol) of triethylamine and 138 mg (2.20 mmol) of 80% hydrazine hydrate were added, and the mixture was stirred at room temperature for 18 h. The mixture was concentrated on a rotary evaporator, taken up in ethyl acetate and washed three times with saturated aqueous sodium chloride solution. The organic phase was dried over sodium sulphate, concentrated on a rotary evaporator and dried under high vacuum. 654 mg (purity 93%, 92% of theory) of the target compound were obtained.

1. concentrationThe mixture was concentrated on a rotary evaporator
2. washwashed three times with saturated aqueous sodium chloride solution
3. dry with materialThe organic phase was dried over sodium sulphate
4. concentrationconcentrated on a rotary evaporator
5. customdried under high vacuum
6. custom654 mg (purity 93%, 92% of theory) of the target compound were obtained