反应详情

温度

150 °C

1.360 g (3.35 mmol) of 1-(2,3-difluorobenzyl)-3-iodo-6-methyl-1H-pyrazolo[3,4-d]pyrimidine and 330 mg (3.68 mmol) of copper(I) cyanide were initially charged in 10 ml of absolute DMSO and the mixture was heated at 150° C. for 2 h. After cooling, the mixture was added to 200 ml of ethyl acetate and washed with a mixture of concentrated aqueous ammonia solution and semisaturated aqueous ammonium chloride solution (v/v=1:3). The organic phase was washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated on a rotary evaporator. 1.040 g (purity 92%, 100% of theory) of the target compound were obtained.

1. temperatureAfter cooling
2. washwashed with a mixture of concentrated aqueous ammonia solution
3. washThe organic phase was washed with saturated aqueous sodium chloride solution
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated on a rotary evaporator
6. custom1.040 g (purity 92%, 100% of theory) of the target compound were obtained