反应详情

温度

150 °C

950 mg (purity 85%, approx. 2.281 mmol) of 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 225 mg (2.509 mmol) of copper(I) cyanide were initially charged in 6 ml of absolute DMSO and the mixture was heated at 150° C. for 2 h. After cooling, the mixture was filtered through Celite and washed through with ethyl acetate and THF. The organic phase was washed with 25% aqueous ammonia solution, saturated aqueous ammonium chloride solution and saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated on a rotary evaporator. 685 mg (purity 84%, 99% of theory) of the target compound were obtained.

1. temperatureAfter cooling
2. filtrationthe mixture was filtered through Celite
3. washwashed through with ethyl acetate and THF
4. washThe organic phase was washed with 25% aqueous ammonia solution, saturated aqueous ammonium chloride solution and saturated aqueous sodium chloride solution
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated on a rotary evaporator
7. custom685 mg (purity 84%, 99% of theory) of the target compound were obtained