1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine → 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

950 mg (purity 85%, approx. 2.281 mmol) of 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 225 mg (2.509 mmol) of copper(I) cyanide were initially charged in 6 ml of absolute DMSO and the mixture was heated at 150° C. for 2 h. After cooling, the mixture was filtered through Celite and washed through with ethyl acetate and THF. The organic phase was washed with 25% aqueous ammonia solution, saturated aqueous ammonium chloride solution and saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated on a rotary evaporator. 685 mg (purity 84%, 99% of theory) of the target compound were obtained.

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