反应详情

44 mg (0.05 mmol) of 2-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were dissolved in 8 ml of absolute DMF, 11 mg (0.01 mmol) of 10% palladium on charcoal were added and hydrogenation was effected under standard hydrogen pressure for 4 h. The reaction mixture was filtered and purified by means of preparative HPLC (eluent: acetonitrile/water, gradient 20:80→100:0). 6 mg of the target compound were obtained (purity 81%; 21% of theory).

1. customfor 4 h
2. filtrationThe reaction mixture was filtered
3. custompurified by means of preparative HPLC (eluent: acetonitrile/water, gradient 20:80→100:0)