Ethyl trifluoroacetate → HCID 58587431, compound

HRID 570561Notes

Reaction equation

HRID 570561 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][NH2:6].[F:7][C:8]([F:15])([F:14])[C:9](OCC)=[O:10]>C(#N)C>[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][NH:6][C:9](=[O:10])[C:8]([F:15])([F:14])[F:7]

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 80511N-Methyl-1,3-propanediamine

Product 1

HCID 58587431HCID 58587431, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
85 °C

Procedure

N-Methyl-1,3-diaminopropane (50 g, 0.56 mol) was dissolved in 200 mL acetonitrile followed by addition of ethyl trifluoroacetate (154 ml, 1.28 mol). The reaction mixture was stirred overnight at 85° C. The solvent was then removed in vacuo to yield the depicted product as a brown oil (101 g, 98.5%).

Workup

  1. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-3516ee60e9e04bb8ae2c19f4017f88b5
Source dataset
uspto-grants-2015_05
Patent number
US09023860B2

Reaction notes

Loading…