Diisopropylethylamine → HCID 71186242, compound

HRID 570566Notes

Reaction equation

HRID 570566 reaction equation
Cl[C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[N:3]=1.Cl.Cl.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:28]=[CH:29][CH:30]=1)[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.CCN(C(C)C)C(C)C>CCO>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][N:25]([C:2]3[S:6][N:5]=[C:4]([C:7]4[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=4)[N:3]=3)[CH2:26][CH2:27]2)[CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 21928608HCID 21928608, compoundHCID 52983548HCID 52983548, compound

Product 1

HCID 71186242HCID 71186242, compoundYield 15.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-chloro-3-(pyridin-4-yl)-1,2,4-thiadiazole (42 mg, 213 μmol), 1-(3-methoxyphenethyl)piperazine dihydrochloride (62.3 mg, 213 μmol) and DIPEA (137 mg, 186 μl, 1.06 mmol) in 10 mL EtOH was stirred for 2.5 h at RT the mixture was filtered, washed with EtOH and dried in vacuo at 50° C. for 2 hours to yield 12.6 mg (15%) of the title compounds as orange solid. MS (m/e): 382.2 (MH+).

Workup

  1. filtrationwas filtered
  2. washwashed with EtOH
  3. customdried in vacuo at 50° C. for 2 hours

Sources & evidence

ORD record
ord-d20141e6b8b14b149016f5ee9f8ed8b2
Source dataset
uspto-grants-2015_05
Patent number
US09023852B2

Reaction notes

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