反应详情

A mixture of 1-(4-methoxyphenethyl)piperazine dihydrochloride (1.04 g, 3.55 mmol), 3,5-dichloro-1,2,4-thiadiazole (500 mg, 3.23 mmol) and DIPEA (1.33 g, 1.8 ml, 10.3 mmol) in 23 mL EtOH was stirred for 1 h at RT. The reaction solution was concentrated in vacuo and the crude product was purified by column chromatography on silica eluting with a gradient formed from heptane and EtOAc to yield, after evaporation of the product containing fraction, 1.06 g (97%) of the title compound as white solid. MS (m/e): 339.2 (MH+).

1. concentrationThe reaction solution was concentrated in vacuo
2. customthe crude product was purified by column chromatography on silica eluting with a gradient
3. customformed from heptane and EtOAc
4. customto yield
5. customafter evaporation of the product
6. additioncontaining fraction, 1.06 g (97%) of the title compound as white solid