HCID 86685402, compound → HCID 86685404, compound

Participants

Reaction Steps

A solution (3 mL) of 6-[(4-methoxybenzyl)amino]-2-propyl-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one (400 mg) in trifluoroacetic acid was stirred with microwave irradiation at 100° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was subjected to aminopropylsilane-bonded silica gel column chromatography (ethyl acetate/hexane) to give the title compound (270 mg) as a solid.

Provenance & Evidence