HCID 86685402, compound → HCID 86685404, compound

HRID 570748Notes

Reaction equation

HRID 570748 reaction equation
COC1C=CC(C[NH:8][C:9]2[N:14]=[C:13]([CH2:15][CH2:16][CH3:17])[N:12]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:20][CH:19]=3)[C:11](=[O:30])[CH:10]=2)=CC=1>FC(F)(F)C(O)=O>[NH2:8][C:9]1[N:14]=[C:13]([CH2:15][CH2:16][CH3:17])[N:12]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][C:26]([F:29])([F:27])[F:28])=[CH:22][CH:23]=2)[C:11](=[O:30])[CH:10]=1

Participants

3

Reactant 1

HCID 86685402HCID 86685402, compound

Product 1

HCID 86685404HCID 86685404, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution (3 mL) of 6-[(4-methoxybenzyl)amino]-2-propyl-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one (400 mg) in trifluoroacetic acid was stirred with microwave irradiation at 100° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was subjected to aminopropylsilane-bonded silica gel column chromatography (ethyl acetate/hexane) to give the title compound (270 mg) as a solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9fc641d60eee4394a5350c53a0c1afc0
Source dataset
uspto-grants-2015_05
Patent number
US09023858B2

Reaction notes

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