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HRID570902

反应详情

EQUATION

反应方程式

HRID 570902 的结构方程式

REACTANTS

反应物

5
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(=O)c3cc(Cl)ccc32)c(C)c1
HCID11362843

N-[4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

C26H23ClN2O3

结构：Cc1cc([N+](=O)[O-])ccc1C(=O)N1CCCC(=O)c2cc(Cl)ccc21
HCID19608065

7-Chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

C18H15ClN2O4

结构：O=C1CCCNc2ccc(Cl)cc21
HCID22903483

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

C10H10ClNO

2 次

结构：CCOC(=O)C1CCN(S(=O)(=O)c2ccc(C)cc2)c2ccc(Cl)cc2C1=O
HCID66981125

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)N2CCCC(=O)c3cc(Cl)ccc32)cc1
HCID66553764

7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one

C17H16ClNO3S

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Processes for the preparation of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one, 7-chloro-1-(2-methyl-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine and 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine were reported in Bioorganic & medicinal chemistry 7 (1999), 1743-1754. According to the journal, 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one can be prepared by reacting 7-chloro-4-ethoxycarbonyl-5-oxo-N-p-toluenesufonyl-2,3,4,5-tetrahydro-1H-1-benzazepine with acetic acid in the presence of hydrochloric acid and water to obtain 7-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine, and then reacted with polyphospholic acid.

WORKUP

后处理

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