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HRID570903

反应详情

EQUATION

反应方程式

HRID 570903 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：Cc1ccccc1C(=O)Cl
HCID70276

Benzoyl chloride, 2-methyl-

C8H7ClO

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：Cc1cc(N)ccc1C(=O)N1CCCC(=O)c2cc(Cl)ccc21
HCID19608232

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

C18H17ClN2O2

PRODUCTS

生成物

1
结构：Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(=O)c3cc(Cl)ccc32)c(C)c1
HCID11362843

N-[4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

C26H23ClN2O3

AUXILIARIES

试剂、催化剂与溶剂

4
结构：O
溶剂HCID962

Water

H2O

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：C1CCCCC1
溶剂HCID8078

Cyclohexane

C6H12

PROCEDURE

实验过程

Typically, 1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine is reacted with 2-methylbenzoylchloride in water immiscible solvent selected from methylene chloride, toluene or cyclohexane in the presence of aqueous inorganic base such as aqueous sodium bicarbonate or aqueous sodium carbonate to form a biphasic system to obtain 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine.

WORKUP

后处理

  1. customto form a biphasic system