HCID 178481978, compound → HCID 178481971, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-phenylethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (250 mg) in 3N HCl (17 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 1 hour and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a 97:3 mixture of hydrochloride and hydroiodide salt (elemental analysis) of the title compound.

Provenance & Evidence