HCID 178481978, compound → HCID 178481971, compound

HRID 570945Notes

Reaction equation

HRID 570945 reaction equation
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:24])[NH:14][CH2:15][C:16](=O)[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:6]2[N:5]=[N:4]1>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:24]=3)=[C:6]2[N:5]=[N:4]1

Participants

3

Reactant 1

HCID 178481978HCID 178481978, compound

Product 1

HCID 178481971HCID 178481971, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Conditions

Temperature
80 °C

Procedure

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-phenylethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (250 mg) in 3N HCl (17 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 1 hour and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a 97:3 mixture of hydrochloride and hydroiodide salt (elemental analysis) of the title compound.

Workup

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

Sources & evidence

ORD record
ord-7164aa028bb74e1086d1642147908ec3
Source dataset
uspto-grants-2015_05
Patent number
US09024018B2

Reaction notes

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