反应详情

Aminoacetaldehyde dimethyl acetal (68 μL, 0.624 mmol) was added to a suspension of methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide (200 mg, 0.568 mmol) in acetonitrile (8 mL) and the mixture was stirred overnight. The precipitate, which formed during the reaction, was filtered and washed successively with water, acetonitrile, ethyl acetate and diethyl ether to give the title product as a bright yellow solid (92 mg, 58%). δH (DMSO-d6): 9.50 (3H, bs), 9.17 (1H, s), 4.69-4.71 (1H, t, J=5.3), 3.95 (3H, s), 3.70-3.72 (2H, d, J=5.3), 3.37 (6H, s).

1. customThe precipitate, which formed during the reaction
2. filtrationwas filtered
3. washwashed successively with water, acetonitrile, ethyl acetate and diethyl ether