HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → Benzylguanine piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | benzylguanine N-Fmoc-piperidine | HCID 136386262 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzylguanine piperidine | HCID 136386263 | — |
Reaction Steps
Weighed into a 1.5 ml Eppendorf tube were 1.8 mg (3 μmol) of benzylguanine-N-Fmoc-piperidine which was dissolved in 190 μl of anhydrous dimethylformamide. 10 μl of piperidine were added and the reaction mixture was left stirring for one hour. The reaction was monitored by HPLC on a Merck Lichrospher RP °18, 5 μm, 125×4.6 column with a gradient of acetonitrile in water containing 0.2% of trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09024022B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-324fa613638340f280d3ce05bbfed671 |
| Source note | uspto-grants-2015_05 |