HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 571068Generated: October 31, 2026
5-(benzyloxy)-1-biphenyl-3-yl-2-methylpyridin-4(1H)-one → 1-biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one
https://huagongshe.com/reaction/571068
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-(benzyloxy)-1-biphenyl-3-yl-2-methylpyridin-4(1H)-one | HCID 67419356 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 1-biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one | HCID 67418555 | — |
Reaction Steps
6.0 g (16.3 mmol) 5-(benzyloxy)-1-biphenyl-3-yl-2-methylpyridin-4(1H)-one was suspended in 150 ml 4 N aq HCl. The reaction mixture was heated at 140° C. for 18 h, then cooled to rt, concentrated in vacuo, suspended in CH2Cl2, and collected by filtration to give 1-biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one. LCMS (M+H)+=278.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09024032B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-b118300d20c94c1dafab2e9808de737d |
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| Source note | uspto-grants-2015_05 |
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