HRID571068

反应详情

EQUATION

反应方程式

HRID 571068 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

CONDITIONS

反应条件

温度
140 °C

PROCEDURE

实验过程

6.0 g (16.3 mmol) 5-(benzyloxy)-1-biphenyl-3-yl-2-methylpyridin-4(1H)-one was suspended in 150 ml 4 N aq HCl. The reaction mixture was heated at 140° C. for 18 h, then cooled to rt, concentrated in vacuo, suspended in CH2Cl2, and collected by filtration to give 1-biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one. LCMS (M+H)+=278.2.

WORKUP

后处理

  1. temperaturecooled to rt
  2. concentrationconcentrated in vacuo
  3. filtrationcollected by filtration