Sodium Bicarbonate → Sodium 2-((4-acetamidophenoxy)carbonylamino)ethanesulfonate

HRID 571164Notes

Reaction equation

HRID 571164 reaction equation
[C:1]([NH:4][C:5]1[CH:20]=[CH:19][C:8]([O:9][C:10]([NH:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:17])=[O:16])=[O:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(=O)([O-])O.[Na+:25]>O>[C:1]([NH:4][C:5]1[CH:20]=[CH:19][C:8]([O:9][C:10]([NH:12][CH2:13][CH2:14][S:15]([O-:18])(=[O:17])=[O:16])=[O:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[Na+:25]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 469130472-((4-Acetamidophenoxy)carbonylamino)ethanesulfonic acid

Product 1

HCID 86731793Sodium 2-((4-acetamidophenoxy)carbonylamino)ethanesulfonateYield 103.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Sodium 2-((4-Acetamidophenoxy)carbonylamino)ethanesulfonic acid (12) was prepared following the General Procedure for the Preparation of Alkali Metal Salts (Procedure B). 4-Acetamidophenoxy)carbonylamino)ethanesulfonic acid (12a) (1.0 g, 3.3 mmol), dissolved in 5 mL of water, was reacted with 275 mg (3.27 mmol; 1.0 eq.) of sodium hydrogencarbonate (NaHCO3) dissolved in 2 mL of water. The mixture was frozen and the solvents lyophilized off to afford 1.10 g (˜quantitative yield) of the title compound (12) as a colorless solid. The material thus obtained was contaminated with some sodium chloride (NaCl) and other sodium salts. Rt=5.024 min. 1H NMR (300 MHz, D2O): δ=7.25 (d, J=9.0 Hz, 2H), 6.97 (d, J=8.7 Hz, 2H), 3.43 (t, J=6.6 Hz, 2H), 2.98 (t, J=6.9 Hz, 2H), 2.00 (s, 3H). LC/MS (ESI): m/z=303.0 [M+H]+, 626.8 [2M+Na]+, 602.8 [2M−H]−.

Workup

  1. customSodium 2-((4-Acetamidophenoxy)carbonylamino)ethanesulfonic acid (12) was prepared
  2. temperatureThe mixture was frozen

Sources & evidence

ORD record
ord-53c0ead76a6e4c8e90aa3d13e344fdd0
Source dataset
uspto-grants-2015_05
Patent number
US09024055B2

Reaction notes

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