反应详情

To a solution of 2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid (2.33 g, 8.50 mmol) in MeOH (35 ml), conc. H2SO4 (3 ml) was added at 0° C. The reaction was warmed at room temperature and stirred for 16 hours. The mixture was poured into an ice/water mixture and neutralized with aqueous NaHCO3. The resulting precipitate was recovered by filtration, washed with water and dried affording methyl 2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetate (2.42 g, 8.40 mmol, 99% yield). MS/ESI+ 288.0 [MH]+.

1. filtrationThe resulting precipitate was recovered by filtration
2. washwashed with water
3. customdried