5,6-Dichloro-pyrimidin-4-ylamine → 5-Chloro-6-{4-[4-(4-fluoro-3-methyl-phenyl)-1-(1-methyl-azetidin-3-ylmethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine

HRID 57132Notes

Reaction equation

HRID 57132 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:11]([CH2:13][CH:14]3[CH2:17][N:16]([CH3:18])[CH2:15]3)[CH:12]=2)=[CH:4][C:3]=1[CH3:25].[Cl:26][C:27]1[C:28]([NH2:34])=[N:29][CH:30]=[N:31][C:32]=1Cl>>[Cl:26][C:27]1[C:28]([NH2:34])=[N:29][CH:30]=[N:31][C:32]=1[N:22]1[CH2:21][CH2:20][CH:19]([C:10]2[N:11]([CH2:13][CH:14]3[CH2:15][N:16]([CH3:18])[CH2:17]3)[CH:12]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:25])[CH:4]=3)[N:9]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 242192625,6-Dichloro-pyrimidin-4-ylamineHCID 1182903044-[4-(4-fluoro-3-methyl-phenyl)-1-(1-methyl-azetidin-3-ylmethyl)-1H-imidazol-2-yl]-piperidine

Product 1

HCID 1182903195-Chloro-6-{4-[4-(4-fluoro-3-methyl-phenyl)-1-(1-methyl-azetidin-3-ylmethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine

Procedure

The title compound was prepared according to the procedure described for the preparation of compound “1” by using 4-[4-(4-fluoro-3-methyl-phenyl)-1-(1-methyl-azetidin-3-ylmethyl)-1H-imidazol-2-yl]-piperidine and 5,6-Dichloro-pyrimidin-4-ylamine. LC-MS (M+H=471, obsd=471).

Workup

  1. customdescribed for the preparation of compound “1”

Sources & evidence

ORD record
ord-1f7b049279784fdfbeffea1fc1f551b1
Source dataset
uspto-grants-2016_09
Patent number
US09434714B2

Reaction notes

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