Hydrochloric Acid → HCID 86681744, compound

HRID 571329Notes

Reaction equation

HRID 571329 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][N:9]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([CH2:23][C:24]([O:26]C)=[O:25])[C:18](=[O:28])[CH2:17]3)[S:10]([CH3:13])(=[O:12])=[O:11])[CH2:3][CH2:2]1.[ClH:29]>O1CCOCC1>[ClH:29].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][N:9]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([CH2:23][C:24]([OH:26])=[O:25])[C:18](=[O:28])[CH2:17]3)[S:10]([CH3:13])(=[O:12])=[O:11])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86681743HCID 86681743, compound

Product 1

HCID 86681744HCID 86681744, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of methyl 2-(5-(N-(2-morpholinoethyl)methylsulfonamido)-2-oxoindolin-1-yl)acetate (0.100 g, 0.243 mmol) in dioxane (5 ml), aqueous 37% HCl (5 ml) was added, and the mixture was stirred at room temperature overnight. The volatiles were removed under vacuum and crude 2-(5-(N-(2-morpholinoethyl)-methylsulfonamido)-2-oxoindolin-1-yl)acetic acid hydrochloride (0.105 g, 0.242 mmol, 100% yield, MS/ESI+ 398.0 [MH]+) was used as such in the next step.

Sources & evidence

ORD record
ord-22aa79c1d9674940a3035f1ff4214c0c
Source dataset
uspto-grants-2015_05
Patent number
US09024027B2

Reaction notes

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