反应详情

To a solution of tert-butyl 2-(5-(methylsulfonamidomethyl)-1,3-dioxoisoindolin-2-yl)acetate (0.200 g, 0.543 mmol) in DCM (10 ml) cooled to 0° C., TFA (0.418 ml, 5.43 mmol) was added drop wise, and the solution stirred at room temperature for 24 hours. The solvent was removed under vacuum and dried to give 2-(5-(methylsulfonamidomethyl)-1,3-dioxoisoindolin-2-yl)acetic acid as a yellow solid (0.170 g, 0.544 mmol, yield considered to be quantitative, MS/ESI+ 312.9 [MH]+). This product was used without any further purification.

1. customThe solvent was removed under vacuum
2. customdried
3. customto give