Trifluoroacetic acid → HCID 118290350, compound

HRID 57135Notes

Reaction equation

HRID 57135 reaction equation
C(OC([N:8]1[C:12]([C:13]2[C:14]([NH2:44])=[N:15][CH:16]=[N:17][C:18]=2[N:19]2[CH2:24][CH2:23][CH:22]([C:25]3[N:26]([CH2:38][CH2:39][N:40]4[CH2:43][CH2:42][CH2:41]4)[CH:27]=[C:28]([C:30]4[CH:35]=[CH:34][C:33]([F:36])=[C:32]([CH3:37])[CH:31]=4)[N:29]=3)[CH2:21][CH2:20]2)=[CH:11][CH:10]=[N:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:40]1([CH2:39][CH2:38][N:26]2[CH:27]=[C:28]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[C:32]([CH3:37])[CH:31]=3)[N:29]=[C:25]2[CH:22]2[CH2:21][CH2:20][N:19]([C:18]3[N:17]=[CH:16][N:15]=[C:14]([NH2:44])[C:13]=3[C:12]3[NH:8][N:9]=[CH:10][CH:11]=3)[CH2:24][CH2:23]2)[CH2:43][CH2:42][CH2:41]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118290299HCID 118290299, compound

Product 1

HCID 118290350HCID 118290350, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-(4-amino-6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-pyrazole-1-carboxylic acid tert-butyl ester (1.00 eq.) in DCM (1 ml), was added trifluoro-acetic acid (0.5 ml). The reaction mixture was stirred at RT for 30 min. After removal of the solvent, the crude was purified by HPLC to yield the title compound. LC-MS (M+H=502, obsd=502).

Workup

  1. customAfter removal of the solvent
  2. customthe crude was purified by HPLC

Sources & evidence

ORD record
ord-d2ac954e01b943c987a2a3d3692de65e
Source dataset
uspto-grants-2016_09
Patent number
US09434714B2

Reaction notes

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