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HRID571359

反应详情

EQUATION

反应方程式

HRID 571359 的结构方程式

REACTANTS

反应物

2
结构：NS(N)(=O)=O
HCID82267

Sulfamide

H4N2O2S

结构：CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CNC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1
HCID86708896

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CN(S(N)(=O)=O)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1
HCID89928724

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCCOC
溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

A mixture of Example 1 (42 mg, 0.0896 mmol) and sulfamide (15 mg, 0.155 mmol) in DME (1 mL) in a sealed tube was heated at 90° C. overnight. After condensation, the residue was purified by CombiFlash (eluent: 5% 7N NH3 in methanol in DCM) to give the product as a yellow oil. LC/MS: C23H32F3N5O5S: m/z 548.2 (M+H).

WORKUP

后处理

  1. customAfter condensation
  2. customthe residue was purified by CombiFlash (eluent: 5% 7N NH3 in methanol in DCM)