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HRID571412

反应详情

EQUATION

反应方程式

HRID 571412 的结构方程式

REACTANTS

反应物

2
结构：COC[C@@H](NC(N)=O)c1ccccc1
HCID89524417

N-[(1S)-2-Methoxy-1-phenylethyl]urea

C10H14N2O2

结构：FC(F)(F)c1n[nH]c2cc(Cl)ncc12
HCID178506289

未命名化合物

PRODUCTS

生成物

1
结构：COC[C@@H](NC(=O)Nc1cc2[nH]nc(C(F)(F)F)c2cn1)c1ccccc1
HCID178495747

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 30 (Step 1), 6-chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine was reacted with (S)-1-(2-methoxy-1-phenylethyl)urea (BrettPhos precatalyst, KOtBu, dioxane, 90° C., overnight) to provide 1-[(1S)-2-methoxy-1-phenylethyl]-3-[3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]urea. MS ESI calc'd. for C17H16F3N5O2[M+1]+ 380, found 380.