(4-(2-Hydroxyethoxy)phenyl)(4-methoxyphenyl)methanone → 1-(4-(2-Hydroxyethoxy)phenyl)-1-(4-methoxyphenyl)prop-2-yn-1-ol

HRID 571559Notes

Reaction equation

HRID 571559 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[O:12])=[CH:7][CH:6]=1.F[C:22]1C=CC(C(C2C=CC(OCCO)=CC=2)=O)=C[CH:23]=1>>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=2)([OH:12])[C:22]#[CH:23])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 66778395(4-(2-Hydroxyethoxy)phenyl)(4-methoxyphenyl)methanoneHCID 67170561(4-Fluorophenyl)(4-(2-hydroxyethoxy)phenyl)methanone

Product 1

HCID 866664251-(4-(2-Hydroxyethoxy)phenyl)-1-(4-methoxyphenyl)prop-2-yn-1-ol

Procedure

The procedure of Step 1 of Example 5 of U.S. Pat. No. 7,465,415B2 was followed except that the product of Step 5 above was used in place of (4-fluorophenyl)(4-(2-hydroxyethoxy)phenyl)methanone to produce 1-(4-(2-hydroxyethoxy)phenyl)-1-(4-methoxyphenyl)prop-2-yn-1-ol. The product was used without further purification.

Sources & evidence

ORD record
ord-065a545b96a84bb1a1f039e41887c8b5
Source dataset
uspto-grants-2015_05
Patent number
US09028728B2

Reaction notes

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