6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 71748063, compound

HRID 571642Notes

Reaction equation

HRID 571642 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[S:14]1[C:23]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18][C:17]=2[NH:16][C:15]1=[O:24]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:20]3[CH2:21][CH2:22][C:23]4[S:14][C:15](=[O:24])[NH:16][C:17]=4[CH2:18][CH2:19]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 86697866HCID 86697866, compound

Product 1

HCID 71748063HCID 71748063, compound

Procedure

The title compound was prepared in accordance with the general method of example 1 from 6-Bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 3,4,5,6,7,8-hexahydro-thiazolo[4,5-d]azepin-2-one. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 40 mg (49% of theory). ESI-MS: m/z=394 (M+H)+; Rt(HPLC): 1.11 min. (Method J).

Workup

  1. customThe reaction mixture was purified by HPLC chromatography

Sources & evidence

ORD record
ord-237e2c679c364f85a787620e14b811ce
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

Loading…