{2-[Benzenesulfonyl-(4-fluoro-3-trifluoromethyl-benzyl)-amino]-benzo[b]thiophen-3-yl}-carbamic acid t-butyl ester → HCID 57920353, compound

HRID 57168Notes

Reaction equation

HRID 57168 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]2[CH:38]=[CH:37][CH:36]=[CH:35][C:10]=2[S:11][C:12]=1[N:13]([S:26]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([C:22]([F:25])([F:24])[F:23])[CH:16]=1)(C)(C)C>Cl.O1CCOCC1.C(OCC)C>[NH2:7][C:8]1[C:9]2[CH:38]=[CH:37][CH:36]=[CH:35][C:10]=2[S:11][C:12]=1[N:13]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([C:22]([F:25])([F:24])[F:23])[CH:16]=1)[S:26]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)(=[O:27])=[O:28]

Participants

5

Reactant 1

HCID 57920407{2-[Benzenesulfonyl-(4-fluoro-3-trifluoromethyl-benzyl)-amino]-benzo[b]thiophen-3-yl}-carbamic acid t-butyl ester

Product 1

HCID 57920353HCID 57920353, compoundYield 78.6%

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

Compound 509-A (1.0 g, 1.72 mmol) was dissolved in 4N HCl in dioxane (20 mL) and stirred at ambient temperature for 18 h. The resultant suspension was diluted with diethyl ether, filtered, washed with diethyl ether and dried under vacuo to afford 0.65 g of compound 509-B. MS: m/z 481.0 (MH+).

Workup

  1. filtrationfiltered
  2. washwashed with diethyl ether
  3. customdried under vacuo

Sources & evidence

ORD record
ord-36f005a0ab3b4aaebf807385e49d31d0
Source dataset
uspto-grants-2016_09
Patent number
US09434711B2

Reaction notes

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