Hydrochloric Acid → 3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride

HRID 571803Notes

Reaction equation

HRID 571803 reaction equation
C([O:5][C:6](=[O:28])[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:10]1)(C)(C)C.[ClH:29].O1CCOCC1>>[ClH:29].[O:21]([C:18]1[CH:17]=[CH:16][C:15]([CH:11]2[O:12][CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:6]([OH:28])=[O:5])[CH2:10]2)=[CH:20][CH:19]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 666539703-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester

Product 1

HCID 666540443-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride

Procedure

3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester (49 mg) was treated with HCl in 1,4-dioxane (0.5 mL; 4.0 mol/L, 2 mmol) and shaken overnight at room temperature. Removal of the solvent in vacuo yielded 3-[2-(4-phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride as an amorphous broken white powder (48 mg). Rt=1.60 min.

Workup

  1. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-219dfef5b85e411296cf0a6b0069e3ea
Source dataset
uspto-grants-2015_05
Patent number
US09029371B2

Reaction notes

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