Hydroxylamine → HCID 87420607, compound

HRID 571955Notes

Reaction equation

HRID 571955 reaction equation
[NH2:1][OH:2].[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([CH2:15][CH3:16])[CH:6]=1)#[N:4]>CCO>[NH2:4]/[C:3](=[N:1]/[OH:2])/[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([CH2:15][CH3:16])[CH:6]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 2735222N-(4-cyano-2-ethylphenyl)acetamide

Product 1

HCID 87420607HCID 87420607, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Hydroxylamine (5.95 g, 90.0 mmol, 50 wt. % aq. solution) was added to a stirred solution of N-(4-cyano-2-ethylphenyl)acetamide (5.65 g, 30.0 mmol) in EtOH (70 mL), and the resulting mixture was heated to 90° C. After 2 h, the reaction mixture was cooled to rt and concentrated in vacuo to afford the title compound i-5a. m/z (ES) 222 (MH)+

Workup

  1. temperaturethe reaction mixture was cooled to rt
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-74b2edd99f6948ee942a4f991387db57
Source dataset
uspto-grants-2015_05
Patent number
US09029377B2

Reaction notes

Loading…