Hydrochloric Acid → HCID 11977100, compound

Participants

Reaction Steps

To a solution of compound AE or AM′ (1.0 equiv.) in pyridine under argon atmosphere and cooled at −20° C./0° C., the selected amine (5.0 equiv.) and phosphorus oxychloride (1.5 equiv) were successively added. After 30-40 min at 0° C., the reaction was treated with HCl 1M and extracted with AcOEt. The organic layer was washed with brine, dried over MgSO4 and concentrated under reduced pressure. Purification by flash-chromatography afforded the product.

Provenance & Evidence