反应详情

To a solution of compound AE or AM′ (1.0 equiv.) in pyridine under argon atmosphere and cooled at −20° C./0° C., the selected amine (5.0 equiv.) and phosphorus oxychloride (1.5 equiv) were successively added. After 30-40 min at 0° C., the reaction was treated with HCl 1M and extracted with AcOEt. The organic layer was washed with brine, dried over MgSO4 and concentrated under reduced pressure. Purification by flash-chromatography afforded the product.

1. extractionextracted with AcOEt
2. washThe organic layer was washed with brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customPurification by flash-chromatography
6. customafforded the product