HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 54514951, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-Cyclopropyl-3-Oxopropionic Acid Methyl Ester | HCID 10130016 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 54514951 | HCID 54514951 | — |
Reaction Steps
A solution of methyl 3-cyclopropyl-3-oxopropionate (4.8 g, 34 mmol) in methanol (80 mL) is mixed with hydroxylamine hydrochloride (2.6 g, 38 mmol) and triethylamine (5.3 mL, 38 mmol), and the mixture is heated under reflux for 2 h. The solvent is distilled out in vacuo. The residue is taken up in EtOAc and filtered through silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029400B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-2828ebb628654bf78b697f8ea2ff290d |
| Source note | uspto-grants-2015_05 |