Triethylamine → HCID 54514951, compound

HRID 572227Notes

Reaction equation

HRID 572227 reaction equation
[CH:1]1([C:4](=O)[CH2:5][C:6]([O:8]C)=[O:7])[CH2:3][CH2:2]1.Cl.NO.C([N:16](CC)CC)C>CO>[CH:1]1([C:4]2[NH:16][O:8][C:6](=[O:7])[CH:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

Product 1

HCID 54514951HCID 54514951, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 3-cyclopropyl-3-oxopropionate (4.8 g, 34 mmol) in methanol (80 mL) is mixed with hydroxylamine hydrochloride (2.6 g, 38 mmol) and triethylamine (5.3 mL, 38 mmol), and the mixture is heated under reflux for 2 h. The solvent is distilled out in vacuo. The residue is taken up in EtOAc and filtered through silica gel.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 2 h
  3. distillationThe solvent is distilled out in vacuo
  4. filtrationfiltered through silica gel

Sources & evidence

ORD record
ord-2828ebb628654bf78b697f8ea2ff290d
Source dataset
uspto-grants-2015_05
Patent number
US09029400B2

Reaction notes

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