反应详情

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(2-chloro-pyridin-4-yl)imidazolidin-2-one (I-33b: 75 mg, 0.38 mmol) was reacted with and 3-bromo-4-cyclopentyl-pyridine (I-34c: 95 mg, 0.418 mmol) copper iodide (7.22 mg, 0.38 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (16.21 mg, 0.114 mmol), potassium phosphate (241.9 mg, 1.15 mmol) and 1,4-dioxane (5 mL) to yield the crude product. Purified by preparative HPLC afforded 2.50 mg of the product (2% yield).

1. customreagents and reaction conditions
2. customto yield the crude product
3. customPurified by preparative HPLC