4-Methylmorpholine → HCID 178434652, compound

HRID 57250Notes

Reaction equation

HRID 57250 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1.CN1CCOCC1>C(Cl)(Cl)Cl>[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][S:17]([C:15]2[CH:14]=[CH:13][C:11]3[N:12]=[C:8]([C:3]4[C:4]([CH3:7])=[N:5][NH:6][C:2]=4[NH2:1])[S:9][C:10]=3[CH:16]=2)(=[O:19])=[O:18])=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 673264-FluorobenzylamineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434652HCID 178434652, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

the title compound (8 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (75 mg, 0.23 mmol), 4-fluorobenzylamine (29 μL, 0.25 mmol) and PS-NMM (0.22 g, 0.45 mmol) in 4 mL of chloroform. MS (m/z, ES+): 418.3 (M+1, 100%). Yield=9%.

Sources & evidence

ORD record
ord-52573d8293704418bd3309663f2bdf96
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

Loading…